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M94A3034.TXT
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1994-10-25
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Document 3034
DOCN M94A3034
TI Serologic and viral correlates of HIV-1 disease progression; a
multicenter AIDS cohort report. MACS Study. Multicenter AIDS Cohort
Study.
DT 9412
AU Black C; Farzadegan H; Henrard D; Saah A; Renaldo C; Detel R; Phair J;
Johns Hopkins University, Baltimore, MD 21205.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):169 (abstract no. PB0102). Unique
Identifier : AIDSLINE ICA10/94369541
AB OBJECTIVE: To compare HIV viral RNA and P24 antigen as well as hemoral
response to the infection among seroconverters (SC) who developed AIDS
in less than 3 years with SC who did not develop AIDS. Seroprevalents
(SP) with no CD4 decline in 7 years of follow up were also used as
control. METHOD: 17 SCs who developed AIDS in 3 years, 42 SCs who were
AIDS free and 56 SPs with no or minimal CD4 counts were selected from
4952 gay/bisexual men participating in Multicenter AIDS Cohort Study
(MACS). HIV-1 P24 antigen and virion RNA as well as neoptrin, B-2
microglobulin, Interferon X, IgG, IgM, IgA and quantitative HIV-1
serology were performed in plasma. RESULTS: Levels of P24 antigen was
significantly higher at first positive visit and visit closest to AIDS
in SCs with AIDS less than 3 years. (0.02 and 0.004 respectively).
Similarly titer of HIV RNA was 10(4.2) copies/ml and raised in rapid
progressor as compared to 10(3.4) in non progressor and remained stable.
Anti P24 and P17 was different in two groups (P = 0.02 and 0.0002
respectively). Data on neopterin, B-2, Ig's and Interferon show no or
narrow correlation. CONCLUSION: The quantitation of viral antigen and
RNA and anti-HIV antibodies serve as predictors of progression to
disease stage among gay/bisexual men.
DE beta 2-Microglobulin/METABOLISM Acquired Immunodeficiency
Syndrome/CLASSIFICATION/DIAGNOSIS/ *IMMUNOLOGY Biological
Markers/*BLOOD Biopterin/ANALOGS & DERIVATIVES/BLOOD Bisexuality
Cohort Studies Follow-Up Studies Homosexuality Human HIV
Antibodies/BLOOD HIV Core Protein p24/BLOOD HIV
Seropositivity/CLASSIFICATION/DIAGNOSIS/*IMMUNOLOGY
*HIV-1/IMMUNOLOGY/PHYSIOLOGY Immunoglobulins/BLOOD Interferons/BLOOD
Leukocyte Count Male RNA, Viral/BLOOD T4 Lymphocytes/IMMUNOLOGY
Virus Replication/*IMMUNOLOGY MEETING ABSTRACT MULTICENTER STUDY
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).